The Entourage Effect and CBD: What Does It Mean?

entourage effect structure

There are around 120 distinct Phytocannabinoids found in cannabis plants. These Phytocannabinoids interact with the endocannabinoid system, producing entourage effects, which help your body maintain homeostasis or balance.
Two of the more well-studied and popular Phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). CBD and THC are used in several ways, and they can be taken independently or together.

Some studies show that combining them with smaller chemical components found in the cannabis plant, called terpenes, is better than taking THC or CBD alone.

What Is Entourage Effect?

Do you want to know what the entourage effect is? No, not the movie Entourage- the effect it has on your body when you take CBD to isolate! The Entourage Effect refers to the heightened benefits of cannabinoids such as CBD when numerous substances operate synergistically rather than alone. The entourage effects refer to this synergistic effect.

The long history of uses of marijuana for medical purposes is known to all. Everyone is familiar with CBD and THC . However, hemp includes much more than those two cannabinoids.
Consider two football teams competing against each other. Team red has only one player who does all of the kickings, stealing and trying to score goals, whereas team blue has all five players doing different things.

Which team would triumph? Team blue will prevail.

What Does the Researchers Says About It?

So, according to research, what is the entourage effect? That is the critical question to ask yourself when researching CBD and any other medication. The research can often enlighten us as to what we’re missing. It all started in 1998 when Professors Raphael Mechoulam and Shimon Ben-Shabat discovered that the Endocannabinoid System had an ‘entourage effect’ when they discovered plant chemicals significantly boosted the activation of human receptors.

These receptors, which interact with our Endocannabinoid System, play an essential role in regulating and balancing various bodily functions, including immune response, cell communication, sleep cycles, memory, etc. John McPartland and Ethan Russo, two well-known academics, wrote a study titled: Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts in 2001.

This study article investigates Professors Mechoulam and Ben-assertions Shabat’s about how cannabinoids interact with secondary chemicals like terpenes and flavonoids. Their study discovered evidence that extracts high in cannabinoids and terpenes elevated pharmacological activities, which reinforced and widened clinical applications and improved the therapeutic index.

What is the entourage effect feel like? To summarize, terpenes enhance the effects of cannabinoids and combining terpenes with cannabinoids results in a significant variation in effects.

The Entourage effect

Cannabinoids And Terpenes

Cannabinoids are chemical substances formed from hemp and cannabis compounds that interact with cannabinoid receptors present throughout the human endocannabinoid system. The phenomenon of cannabinoids activating the CB1 and CB2 receptors in the brain and body is responsible for cannabis’ therapeutic advantages. When CB1 and CB2 receptors are active, we can increase the operation of our body’s nervous systems and organs.

Cannabinoids and terpenes form in the resin glands, or trichomes, of cannabis plants’ flowers and leaves. Many different plants produce cannabinoids, but cannabis has the greatest concentration. Terpenes, on the other hand, are different compounds but just as important.

Understanding terpenes is essential for newcomers to cannabis; they are just as vital as cannabinoids for self-medicating. According to research, we can no longer examine the strength of THC and CBD extracts in a strain. Terpene concentration can deliver the same advantages as potency and cannabinoid content.

Terpenes are responsible for cannabis’s aroma and taste. Tangerine Dream and Super Lemon Haze feature strong citrus scents, while Blackberry Kush and Strawberry Cough have softer, fruitier undertones. Take a smell of Sour Diesel, and you’ll understand why many adore these potent, skunky buds.

Advantages Of the Entourage Effect

There are many advantages to the entourage effect, especially to people suffering from various health conditions. Cannabinoids perform better with a mix of cannabinoids, terpenes, and flavonoids than with a full spectrum CBD solution that has fewer chemicals or, worse, simply pure CBD.

Don’t forget about the two football teams’ comparison. Which team do you think will come out on top? The team has five players who all work together to pass, defend, and try to score, or which side has only one player who does everything? And don’t forget about what the research says. When humans take cannabis, these molecules, which scientists call ‘endocannabinoids,’ can interface with these neurotransmitters on a cellular level.

Don’t forget that the endocannabinoid system refers to the network of these endocannabinoids in our body. When our neurological system falters, cannabis-derived substances can assist our bodies in regaining their natural balance and stability. This idea underpins cannabis’s use as a medication.

Disadvantages Of the Entourage Effect

Researchers suspicious of the entourage effect point to a lack of controlled, double-blind laboratory experiments to confirm its existence. The entourage effect is a complex process to detect and recognize by definition. Advocates for the entourage effect accept the present research’s limitations. The gist of this is that it’s true that there isn’t a lot of research around this effect or how it works on people. However, while it may seem trivial, anecdotal evidence is still significant since it genuinely impacted people’s lives.

The testimony of cannabis users supports the hypothesis that minor changes in cannabinoid and terpene combinations result in diverse user experiences. It appears to imply that new and distinct qualities may develop from the interaction of diverse cannabis chemical components. Even minor changes in the formula may be sufficient to cause medically relevant variations.

While the anecdotal evidence confirming the actuality of the entourage effect may not be definitive, it should be persuasive enough to encourage researchers to pursue the truth.

Is Entourage Effect Real?

Well, it would appear so. With the number of people testifying to its many benefits and the positive impact it’s had on their lives, it’s hard to deny that the entourage effect is legitimate or should at least be taken into consideration.

Is Cannabis More Than Just THC And CBD?

As we’ve seen throughout this whole article, the answer to that question is quite obvious. Yes, there is much more to the cannabis plant than just those two chemical compounds. You can even make delicious cannabis edibles at your home with a few simple steps. So, if more research were done on it, people would be happier and healthier since they’d be able to enjoy the positive side effects of these chemicals.

Final Thoughts

The entourage effect is natural, and it is powerful. Like a well-managed football team, it allows all the compounds to work together as a group to fight back against sleepiness, stress, and lack of appetite. The research shows it.

CBD is one of the most abundant compounds in Cannabis, and Theo Wilkins knows all this is about. He graduated from Duke University in 2010, and since then, he has been working as a writer after securing a job from one of the famous CBD brands. Because CBD is a product that is sourced from Marijuana, there are speculations and controversies about it. Wilkins will educate you on everything you need to know about CBD while he takes time to focus on what CBD can treat. Theo Wilkins has over 500 journals about CBD, and he has a wide variety of knowledge on it. He visits patients with neurological conditions during his leisure hours

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